making muscle wasting history

Transfer of the dystrophin gene, with a viral vector

• Last Edited: 7 Jul 2009
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Adeno-associated virus (AAV) vector is a potential tool of gene therapy for treatment of genetic neuromuscular disorders. It is a non-pathogenic and replication-defective viral vector without any ...

Tags: gene transfer, dystrophin, AAv, viral vector.

Inhibition of the IKK/NF-kappaB pathway by AAV gene transfer improves muscle regeneration in older mdx mice

• Last Edited: 31 Jan 2011
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The ikappaB kinase(IKKalpha, beta and the regulatory subunit IKKgamma) complex regulates nuclear factor of kappaB (NF-kappaB) transcriptional activity, which is unregulated in many chronic in...

Tags: AAV, myofiber, dystrophic muscle regeneration.