making muscle wasting history

Exon Skipping large animal

• Last Edited: 5 May 2009
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16th March 2009 Researchers from Children’s National Medical Center and colleagues in Tokyo publish results, video of first successful trial in dogs with Duchenne muscular dystrophy. WASHING...

Tags: exon skipping, dogs, antisense oligonucleotides, molecular patches, morpholinos.

Gene therapy research demonstrates promising treatment of DMD for the future

• Last Edited: 5 May 2009
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By Matthew WoodMB ChB Cape Town, MA DPhil OxfUniversity of OxfordThe latest announcement of the £150k raised by Action Duchenne to fund the latest research into ‘Exon skipping’, a gene t...

Tags: Exon Skipping, antisense oligonucleotides, peptide nucleic acids, PNA.

2-'O-methyl antisense oligos (PS) targeting exon 44.

• Last Edited: 15 Sep 2010
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BackgroundAntisense-mediated exon skipping is a putative treatment for Duchenne muscular dystrophy (DMD). Using antisense oligonucleotides (AONs), the disrupted DMD reading frame is restored, allo...

Tags: antisense oligonucleotides, Duchenne muscular dystrophy, exon skipping, 28242Omethyl phosphorothioate, phosphorodiamidate morpholino oligomer.

£2.5m research grant for Duchenne Muscular Dystrophy awarded to Oxford researchers

• Last Edited: 15 Apr 2011
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Funding for pioneering research into gene therapy by Action Duchenne has led to further funds for research into this life limiting disease A recent £2.5 million award made by the Health Innovation...

Tags: exon skipping, Duchenne, Duchenne muscular dystrophy, Dr Matthew Wood, Mike Gait, antisense oligonucleotides.