making muscle wasting history

Inhibition of TGF-beta

• Last Edited: 14 Jul 2009
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The transforming growth factor beta (TGFβ) is a protein which inhibits the satellite cells (muscle stem cells) from regenerating muscle tissue. Mdx mice and also Duchenne boys have increa...

Tags: Duchenne Muscular Dystrophy, fibrosis, mdx mice, pirfenidone, TGF946.

MEDICAL ISSUES- PART 1

• Last Edited: 20 Aug 2010
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For a child with Duchenne the primary school years are usually a time of significant change in terms of their independent mobility. When particular changes occur is a little variable but the patte...

Tags: Duchenne muscular dystrophy, MOBILITY, WEAKness in the thighs, physical activies.

2-'O-methyl antisense oligos (PS) targeting exon 44.

• Last Edited: 15 Sep 2010
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BackgroundAntisense-mediated exon skipping is a putative treatment for Duchenne muscular dystrophy (DMD). Using antisense oligonucleotides (AONs), the disrupted DMD reading frame is restored, allo...

Tags: antisense oligonucleotides, Duchenne muscular dystrophy, exon skipping, 28242Omethyl phosphorothioate, phosphorodiamidate morpholino oligomer.

By-passing the nonsense mutation in the 4 CV mouse model of muscular dystrophy by induced exon skipping.

• Last Edited: 17 Sep 2010
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BackgroundDuchenne muscular dystrophy (DMD), a severe neuromuscular disorder, is caused by protein-truncating mutations in the dystrophin gene. Absence of functional dystrophin renders muscle fibr...

Tags: antisense oligomer, B6RosCgDmdmdx4CvJ 4CV mouse, Duchenne muscular dystrophy, exon skipping, morpholino.

An intronic LINE-1 element insertion in the dystrophin gene aborts dystrophin expression and results in duchenne-like muscular dystrophy in the corgi breed

• Last Edited: 4 Feb 2011
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Duchenne muscular dystrophy (DMD) is a dystrophin-deficient lethal muscle disease. To date, the catastrophic muscle wasting phenotype has only been seen in dystrophin-deficient human and dogs. Alt...

Tags: dystrophin, Duchenne muscular dystrophy, DMD.

Targeting Fibrosis in Duchenne Muscular Dystrophy

• Last Edited: 11 Feb 2011
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Duchenne muscular dystrophy (DMD) is the most common genetic muscle disease affecting 1 in 3,500 live male births. It is an X-linked recessive disease caused by a defective dystrophin gene. The di...

Tags: Duchenne muscular dystrophy, Fibrosis, muscle, cell therapies.

Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype.

• Last Edited: 17 Feb 2011
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Molecular, Cellular & Integrative Physiology Program, University of California, Los Angeles, CA.M1 macrophages play a major role in worsening muscle injury in the mdx mouse model of Duchenne m...

Tags: mdx muscles, dystrophy, Duchenne muscular dystrophy.

Duchenne muscular dystrophy - What causes the increased membrane permeability in skeletal muscle?

• Last Edited: 2 Mar 2011
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Duchenne muscular dystrophy is a severe muscle wasting disease caused by a mutation in the gene for dystrophin – a cytoskeletal protein connecting the contractile machinery to a group of pro...

Tags: muscle weakness, atrophy, therapies, Duchenne muscular dystrophy.

GSK2402968 Clinical Development Programme Update

• Last Edited: 15 Apr 2011
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Forty-Eight Week Follow-Up Data from a Phase I/IIa Extension Study of PRO051/GSK2402968 in Subjects with Duchenne Muscular DystrophyThe following Phase I/IIa extension study results were presented...

Tags: Duchenne, DMD, GSK, Duchenne Muscular Dystrophy.

£2.5m research grant for Duchenne Muscular Dystrophy awarded to Oxford researchers

• Last Edited: 15 Apr 2011
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Funding for pioneering research into gene therapy by Action Duchenne has led to further funds for research into this life limiting disease A recent £2.5 million award made by the Health Innovation...

Tags: exon skipping, Duchenne, Duchenne muscular dystrophy, Dr Matthew Wood, Mike Gait, antisense oligonucleotides.