making muscle wasting history

Dystrophin

• Last Edited: 12 Aug 2009
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What is Dystrophin?Dystrophin is a protein which binds to the muscle membrane cells and helps to maintain the muscle cell structure. It acts like a shock absorber for the muscle cells, and enable...

Tags: dystrophin, gene, protein, muscle, muscle cells, duchenne, muscular, dystrophy.

Reading through premature stop codons with PTC124.

• Last Edited: 13 Jul 2009
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In about 13 to 15% of all Duchenne patients, the disease iscaused by a nonsense mutation in the dystrophin gene. This type of mutation is a single-point change that results in the introduction of ...

Tags: Mutation, exon skipping, dystrophy.

Symptoms of Muscular Dystrophy

• Last Edited: 2 Sep 2009
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Some of the symptoms that can be observed are things like Gait problems Waddling gait Falls Difficulty standing up Difficulty In climbing stairs Difficulty descending stairs Lordosis Firm-looking ...

Tags: Creatine Kinase, DYSTROPHY, muscle biopsy, Lordosis.

Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype.

• Last Edited: 17 Feb 2011
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Molecular, Cellular & Integrative Physiology Program, University of California, Los Angeles, CA.M1 macrophages play a major role in worsening muscle injury in the mdx mouse model of Duchenne m...

Tags: mdx muscles, dystrophy, Duchenne muscular dystrophy.