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Genes are functional units of the genetic material in the chromosomes of each cell. This material is desoxyribonucleic acid, DNA. Its structure looks like an intertwined ladder, the double helix. ...
Tags: Gene, DNA, chromosome, cell, exon, RNA, Protein.
The exon skipping technique tries to change a Duchenne mutation into a Becker mutation. If a variation disturbs the reading frame and thus causes Duchenne dystrophy, the reading frame can be resto...
Tags: exon skipping, exon, antisense oligonucleotide, RNA, duchenne.
Background: Trans-splicing strategies for mRNA repair involve engineered transcripts designed to anneal target mRNAs in order to interfere with their natural splicing, giving rise to mRNA chi...
Tags: Minigene, mRNAs, exon, Transsplicing.