making muscle wasting history

Inhibition of TGF-beta

• Last Edited: 14 Jul 2009
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The transforming growth factor beta (TGFβ) is a protein which inhibits the satellite cells (muscle stem cells) from regenerating muscle tissue. Mdx mice and also Duchenne boys have increa...

Tags: Duchenne Muscular Dystrophy, fibrosis, mdx mice, pirfenidone, TGF946.

Targeting Fibrosis in Duchenne Muscular Dystrophy

• Last Edited: 11 Feb 2011
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Duchenne muscular dystrophy (DMD) is the most common genetic muscle disease affecting 1 in 3,500 live male births. It is an X-linked recessive disease caused by a defective dystrophin gene. The di...

Tags: Duchenne muscular dystrophy, Fibrosis, muscle, cell therapies.

Halofuginone and muscular dystrophy.

• Last Edited: 17 Feb 2011
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Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel. pines@agri.huji.ac.il.Muscular dystrophies (MDs) include different inherited diseases that all result in progressive muscle degener...

Tags: Muscle, fibrosis, gene therapy, myoblast, Muscular dystrophies.

Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-?1 blocker.

• Last Edited: 25 Feb 2011
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Fibrosis is a pathological feature observed in patients with Duchenne muscular dystrophy (DMD) and in mdx mice, the experimental model of DMD. We evaluated the effect of suramin, a transforming gr...

Tags: Muscle Nerve, TGF1 blocker, Fibrosis, muscles.