making muscle wasting history

Deacetylase Inhibitors

• Last Edited: 6 May 2009
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Histone deacetylase inhibitors (HDAC inhibitors, HDI) are a class of compounds that interfere with the function of histone deacetylase.Work undertaken on HDAC inhibitors on the mdx mouse (Minetit...

Tags: Deacetylase, Inhibitors, Enzyme, Myostatin, Follistatin.

Alternatively spliced cDNA of follistatin (FS344) delivered by adeno-associated virus (AAV) to muscle.

• Last Edited: 13 Oct 2010
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In most cases, pharmacologic strategies to treat genetic muscle disorders and certain acquired disorders, such as sporadic inclusion body myositis, have produced modest clinical benefits. In these...

Tags: Myostatin Inhibition, follistatin, muscle disease, muscle enhancement.

AAV1-FS344 injected into the quadriceps induced pronounced and durable increases in muscle size and strength in monkey.

• Last Edited: 13 Oct 2010
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Antagonists of myostatin, a blood-borne negative regulator of muscle growth produced in muscle cells, have shown considerable promise for enhancing muscle mass and strength in rodent studies and c...

Tags: follistatin, gene, muscle growth, muscle cells, muscle mass, strength.