making muscle wasting history

Exon Skipping - A review by Dr Karl Bettelheim

• Last Edited: 30 Jul 2010
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Article submitted by Dr Karl Bettelheim published on the 3rd of June 2009 IntroductionCurrently there are three major groups of treatment for Duchenne Muscular Dystrophy (DMD) e...

Tags: exon skipping, cellpenetrating peptide CPP, mRNA, antisenseoligonucleotides AOs, Dystrophin.

Glial dystrophin-associated proteins, laminin and agrin, are downregulated in the brain of mdx mice

• Last Edited: 31 Jan 2011
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Department of human anatomy and histology, University of Bari medical school, Bari ItalyIn this study, we investigated the involvement of dystrophin-associated protein(DAPs) and their relationship...

Tags: mRNA, protein, dystrophin.

The Status of Exon Skipping as a Therapeutic Approach to Duchenne Muscular Dystrophy.

• Last Edited: 11 Mar 2011
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Duchenne muscular dystrophy (DMD) is associated with mutations in the dystrophin gene that disrupt the open reading frame whereas the milder Becker’s form is associated with mutations which ...

Tags: Exon Skipping, adenoassociated virus AAV, mRNA, dystrophin gene.