making muscle wasting history

Dystrophin

• Last Edited: 12 Aug 2009
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What is Dystrophin?Dystrophin is a protein which binds to the muscle membrane cells and helps to maintain the muscle cell structure. It acts like a shock absorber for the muscle cells, and enable...

Tags: dystrophin, gene, protein, muscle, muscle cells, duchenne, muscular, dystrophy.

Utrophin

• Last Edited: 27 May 2009
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Found this interesting article but unfortunately at least 3 years to clinical rials.......http://www.physorg.com/news162569608.htmlNew therapy substitutes missing protein in those with muscular dy...

Tags: utrophin, duchenne, dystrophin, protein, muscle.

ACE-031 (Neuromuscular Disease)

• Last Edited: 8 Jul 2010
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ACE-031 is a novel, muscle-building agent that is being developed for the treatment of patients with neuromuscular diseases with the goal of improving strength and preserving physical function.Wha...

Tags: myostatin, ACE031, Acceleron, muscle.

The future is coming a little closer! - A review by Dr Karl Bettelheim

• Last Edited: 30 Jul 2010
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Article submitted by Dr Karl Bettelheim published on the 8th Decemember 2008In a recent review Nelson and his co-authors (1) from the University of California, Los Angeles, discuss some genetic tr...

Tags: muscle, genetic treatments, antisense oligonucleotide AON.

Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice.

• Last Edited: 11 Oct 2010
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BackgroundMyostatin inhibition is a promising therapeutic strategy to maintain muscle mass in a variety of disorders, including the muscular dystrophies, cachexia, and sarcopenia. Previously descr...

Tags: muscle, Myostatin inhibition, human fiber.

Functional rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO

• Last Edited: 4 Feb 2011
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Splice modulation using antisense oligonucleotides (AOs) has been shown to yield targeted exon exclusion to restore the open reading frame and generate truncated but partially functional dystrophi...

Tags: peptidePMO, muscle, dystrophin protein.

Targeting Fibrosis in Duchenne Muscular Dystrophy

• Last Edited: 11 Feb 2011
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Duchenne muscular dystrophy (DMD) is the most common genetic muscle disease affecting 1 in 3,500 live male births. It is an X-linked recessive disease caused by a defective dystrophin gene. The di...

Tags: Duchenne muscular dystrophy, Fibrosis, muscle, cell therapies.

Halofuginone and muscular dystrophy.

• Last Edited: 17 Feb 2011
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Institute of Animal Sciences, Volcani Center, Bet Dagan, Israel. pines@agri.huji.ac.il.Muscular dystrophies (MDs) include different inherited diseases that all result in progressive muscle degener...

Tags: Muscle, fibrosis, gene therapy, myoblast, Muscular dystrophies.

Peptide-based inhibition of NF-?B rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy.

• Last Edited: 11 Mar 2011
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Deterioration of diaphragm function is one of the prominent factors that contributes to the susceptibility of serious respiratory infections and development of respiratory failure in patients with...

Tags: muscle, therapy.

AAV-mediated gene therapy to the isolated limb in rhesus macaques.

• Last Edited: 18 Mar 2011
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Center for Gene Therapy, The Research Institute at Nationwide Children’s Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, USA.The development of a nonhuman pri...

Tags: gene therapy, limb, muscle, adenoassociated viral AAV.