making muscle wasting history

Stopping myostatin with an antibody.

• Last Edited: 13 Jul 2009
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Adult mdx mice with an inactivated myostatin gene, which, in addition of not having dystrophin also could not make any myostatin, had more normal muscles fibers, less fibrosis (scar tissue), and r...

Tags: muscles, myostatin.

Heregulin ameliorates the dystrophic phenotype in mdx mice with utrophin upregulation.

• Last Edited: 8 Oct 2010
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Duchenne’s muscular dystrophy (DMD) is a fatal neuromuscular disease caused by absence of dystrophin. Utrophin is a chromosome 6-encoded dystrophin-related protein (DRP), sharing functional ...

Tags: Utrophin UpregulationHDAC Inhibition, utrophin, dystrophin, muscles.

Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-?1 blocker.

• Last Edited: 25 Feb 2011
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Fibrosis is a pathological feature observed in patients with Duchenne muscular dystrophy (DMD) and in mdx mice, the experimental model of DMD. We evaluated the effect of suramin, a transforming gr...

Tags: Muscle Nerve, TGF1 blocker, Fibrosis, muscles.