making muscle wasting history

Losartan and TGFβ.

• Last Edited: 14 Jul 2009
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Dr. Ronald Cohn and his co-workers at the Johns Hopkins University School of Medicine in Baltimore are trying to modify the disease by blocking TGFβ and its signaling pathway that leads t...

Tags: Losartan, TGF946, muscular dystrophy.

TREAT-NMD guide to 'Stem Cell Tourism'

• Last Edited: 29 Jan 2010
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TREAT-NMD is aware that new scientific discoveries and innovations can lead to raised expectations and enthusiasm and this may in turn lead to hype, which can be seen as increased publicity and ...

Tags: stem cell tourism, stem cell, tourism, therapies, TREATNMD, hope, hype, neuromuscular disorders, Duchenne, muscular dystrophy, DMD, research.

Imatinib, a new drug on the Muscular Dystrophy block? - A review by Dr Karl Bettelheim

• Last Edited: 30 Jul 2010
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When single papers appear about some new drug or treatment for a complex condition such as DMD, one has to have a certain healthy sense of scepticism, however, when two appear from diverse laborat...

Tags: Imatinib, Muscular Dystrophy.

Restores dystrophin-glycoprotein complex and improves sarcolemma integrity in the mdx

• Last Edited: 22 Sep 2010
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Background— More than 90% of Duchenne muscular dystrophy (DMD) patients develop cardiomyopathy, and many die of cardiac failure. Despite tremendous progress in skeletal muscle gene therapy, f...

Tags: muscular dystrophy, genes, viruses, gene therapy, microdystrophin.

Intramuscular injection of freshly isolated muscle-derived cells from the HCT donor into dog recipients.

• Last Edited: 24 Sep 2010
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Duchenne Muscular Dystrophy (DMD) is the most common and severe form of muscular dystrophy in humans. The goal of myogenic stem cell transplant therapy for DMD is to increase dystrophin expression...

Tags: cell transplant therapy, muscle generation, muscular dystrophy, transplantation, immune tolerance.

Antioxidant Green tea extract decreases muscle necrosis in mdx mice and protects against reactive oxygen species.

• Last Edited: 13 Oct 2010
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Background: Duchenne muscular dystrophy is a severe X-linked congenital disorder characterized by lethal muscle wasting caused by the absence of the structural protein dystrophin. Objective: Becau...

Tags: Green tea, muscular dystrophy, reactive oxygen species, antioxidant, prevention, muscle necrosis, mdx mice, dystrophin, Xlinked congenital disease.

Oxidative stress by monoamine oxidases is causally involved in myofiber damage in muscular dystrophy.

• Last Edited: 31 Jan 2011
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Department of biomedical sciencesSeveral studies documented the key role of oxidative stress and abnormal production of reactive oxygen species (ROS) in the pathophysiology of muscular dystrophies...

Tags: reactive oxygen speciesROS, muscular dystrophy, Oxidative stress, Oxidative, reactive oxygen species ROS.

Co-administration of ibuprofen and nitric oxide is an effective experimental therapy for muscular dystrophy, with immediate applicability to humans

• Last Edited: 11 Mar 2011
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Background and purpose: Current therapies for muscular dystrophy are based on corticosteroids. Significant side effects associated with these therapies have prompted several studies aimed at ident...

Tags: nitric oxide, inflammation, muscular dystrophy, skeletal muscle regeneration, diet, therapy.

Update on the Therapeutic approaches to muscular dystrophy

• Last Edited: 10 May 2011
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This is a summary of the article written by Aurelie Goyenvalle, Jane T Seto, Kay E Davies and Jeffrey Chamberlain, which was published by Oxford University Press on 5 April 2011.The article is a r...

Tags: exon skipping, gene therapy, Viral Vector, Dystrophin, rAAV, Antisense Oligonucleotide, PMO, PPMO, Duchenne, muscular dystrophy, Utrophin.