making muscle wasting history

Deacetylase Inhibitors

• Last Edited: 6 May 2009
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Histone deacetylase inhibitors (HDAC inhibitors, HDI) are a class of compounds that interfere with the function of histone deacetylase.Work undertaken on HDAC inhibitors on the mdx mouse (Minetit...

Tags: Deacetylase, Inhibitors, Enzyme, Myostatin, Follistatin.

Inhibition of myostatin

• Last Edited: 13 Jul 2009
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Myostatin is produced in muscle cells as an inactive protein consisting of 375 amino acids. It circulates in the bloodstream as an inactive molecule. When it’s so-called propeptide is degrade...

Tags: Myostatin, protein, bloodstream.

Stopping myostatin with its propeptide.

• Last Edited: 13 Jul 2009
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Prof. Keith Foster at the School of Biological Sciences of the University of London and his colleagues used a stabilized propeptide to bind myostatin and thus to inactivate it. They transferred th...

Tags: plasmids, propeptides, myostatin.

Increasing muscle mass and strength by stopping myostatin

• Last Edited: 13 Jul 2009
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Follistatin-344 is a hormone-like protein consisting of a chain of 344 amino acids which is activated to follistatin-315 by splitting off 29 amino acids from its carboxyl end. Follistatin-315 toge...

Tags: Follistain, myostatin, muscle mass.

Stopping myostatin with an antibody.

• Last Edited: 13 Jul 2009
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Adult mdx mice with an inactivated myostatin gene, which, in addition of not having dystrophin also could not make any myostatin, had more normal muscles fibers, less fibrosis (scar tissue), and r...

Tags: muscles, myostatin.

ACE-031 (Neuromuscular Disease)

• Last Edited: 8 Jul 2010
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ACE-031 is a novel, muscle-building agent that is being developed for the treatment of patients with neuromuscular diseases with the goal of improving strength and preserving physical function.Wha...

Tags: myostatin, ACE031, Acceleron, muscle.

Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of duchenne muscular dystrophy.

• Last Edited: 24 Jan 2011
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Modulation of transforming growth factor-beta (TGF-beta) signalling to promote muscle growth hold tremendous promise for the muscular dystrophies and other disorders involving the loss of function...

Tags: Myostatin, adenoassociate virus AAV, activin IIB.