making muscle wasting history

Dosing regiment

• Last Edited: 28 May 2009
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this is potentially important ...Dosing regimen has a significant impact on the efficiency of morpholino oligomer-induced exon skipping in mdx mice.http://www.ncbi.nlm.nih.gov/pubmed/194697091: Hu...

Tags: duchenne, dystrophin, dose, peptide, exon skipping, pmo, morpholino.

Phosphorodiamidate morpholino oligomer targeting exon 51.

• Last Edited: 13 Sep 2010
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BackgroundMutations that disrupt the open reading frame and prevent full translation of DMD, the gene that encodes dystrophin, underlie the fatal X-linked disease Duchenne muscular dystrophy. Olig...

Tags: exon skipping, PMO, morpholino therapy.

Antisense-induced myostatin exon skipping leads to muscle hypertrophy in mice following octa guanidine morpholino oligomer treatment.

• Last Edited: 13 Dec 2010
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Myostrain is a negative regulator of muscle mass, and several strategies are being developed to knockdown its expression to improve muscle-wasting conditions. Strategies using antimyostrain-blocki...

Tags: Myostrain, PMO, muscle strength, exon skipping.

Update on the Therapeutic approaches to muscular dystrophy

• Last Edited: 10 May 2011
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This is a summary of the article written by Aurelie Goyenvalle, Jane T Seto, Kay E Davies and Jeffrey Chamberlain, which was published by Oxford University Press on 5 April 2011.The article is a r...

Tags: exon skipping, gene therapy, Viral Vector, Dystrophin, rAAV, Antisense Oligonucleotide, PMO, PPMO, Duchenne, muscular dystrophy, Utrophin.