making muscle wasting history

Genes

• Last Edited: 6 Apr 2009
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Genes are functional units of the genetic material in the chromosomes of each cell. This material is desoxyribonucleic acid, DNA. Its structure looks like an intertwined ladder, the double helix. ...

Tags: Gene, DNA, chromosome, cell, exon, RNA, Protein.

Exon Skipping

• Last Edited: 6 Apr 2009
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The exon skipping technique tries to change a Duchenne mutation into a Becker mutation. If a variation disturbs the reading frame and thus causes Duchenne dystrophy, the reading frame can be resto...

Tags: exon skipping, exon, antisense oligonucleotide, RNA, duchenne.

Exon skipping with U7 gene transfer

• Last Edited: 6 Jul 2009
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This is a gene therapy approach for Duchenne muscular dystrophy (DMD), based on the exon-skipping strategy and is currently under development. This approach consists of interacting with the splici...

Tags: gene, DNA, exon skipping, rna, U7, gene transfer.