making muscle wasting history

Inhibition of TGF-beta

• Last Edited: 14 Jul 2009
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The transforming growth factor beta (TGFβ) is a protein which inhibits the satellite cells (muscle stem cells) from regenerating muscle tissue. Mdx mice and also Duchenne boys have increa...

Tags: Duchenne Muscular Dystrophy, fibrosis, mdx mice, pirfenidone, TGF946.

Losartan and TGFβ.

• Last Edited: 14 Jul 2009
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Dr. Ronald Cohn and his co-workers at the Johns Hopkins University School of Medicine in Baltimore are trying to modify the disease by blocking TGFβ and its signaling pathway that leads t...

Tags: Losartan, TGF946, muscular dystrophy.