making muscle wasting history

Utrophin update April 2009

• Last Edited: 1 May 2009
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This is the latest update from Biomarin with regard to Utrophin.In the first quarter of 2009, BioMarin recorded impairment loss on investments of $5.9 million, comprised of $1.4 million related to...

Tags: utrophin, biomarin, summit.

Sarcospan

• Last Edited: 1 May 2009
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Sarcospan, a little protein for a big problem The overlooked and undervalued protein, sarcospan, just got its moment in the spotlight. Peter et al. now show that adding it to muscle cells might am...

Tags: sarcospan, membrane, utrophin, cell.

Utrophin

• Last Edited: 27 May 2009
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Found this interesting article but unfortunately at least 3 years to clinical rials.......http://www.physorg.com/news162569608.htmlNew therapy substitutes missing protein in those with muscular dy...

Tags: utrophin, duchenne, dystrophin, protein, muscle.

Summit pass pre-clinical development to Biomarin

• Last Edited: 29 May 2009
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New investor email out today, see below:Restructuring of Duchenne muscular dystrophy agreement with BioMarinSummit and BioMarin have recently restructured their agreement for the Duchenne muscular...

Tags: summit, biomarin, utrophin, utrophin upregulation, SMT C1100.

Upregulation of utrophin to replace dystrophin.

• Last Edited: 8 Jul 2009
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Utrophin is a protein with a structure and function very similar to dystrophin. In humans, its gene is located on chromosome 6, has 75 exons, and is about one million base pairs long. Utrophin is ...

Tags: Dystrophin, utrophin, membrane.

Investigating Utrophin as a therapy for Duchenne Muscular Dystrophy

• Last Edited: 30 Aug 2009
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Professor Dame Kay Davies CBE FRS FMedSciDirector MRC Functional Genomics UnitHead of Department, Physiology, Anatomy and Genetics,University of OxfordDuchenne muscular dystrophy (DMD) is caused b...

Tags: Utrophin Upregulation, Utrophin, Treatment for Duchenne, Professor Dame Kay Davies.

‘Fall Seven Times, Stand Up Eight’ - A review by Dr Karl Bettelheim

• Last Edited: 30 Jul 2010
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Article submitted by Dr Karl Bettelheim published on the 24th of June 2009 IntroductionWhile, I have always tried to bring good or hopeful or it least interesting developments, ...

Tags: dystrophin, Utrophin, myoblasts, X chromosome.

Heregulin ameliorates the dystrophic phenotype in mdx mice with utrophin upregulation.

• Last Edited: 8 Oct 2010
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Duchenne’s muscular dystrophy (DMD) is a fatal neuromuscular disease caused by absence of dystrophin. Utrophin is a chromosome 6-encoded dystrophin-related protein (DRP), sharing functional ...

Tags: Utrophin UpregulationHDAC Inhibition, utrophin, dystrophin, muscles.

Activated PI3/AKT/mTOR pathway and Ameliorates Pathology in a Mouse Model.

• Last Edited: 8 Oct 2010
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Duchenne muscular dystrophy is a lethal neuromuscular disease that currently has no effective therapy. Transgenic overexpression of the 7 integrin in mdx/utrn–/– mice, a model of Duchenn...

Tags: utrophin, Valproic acid.

Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx mice

• Last Edited: 17 Feb 2011
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Abstr : Duchenne muscular dystrophy (DMD) is caused by mutations in dystrophin and the subsequent disruption of the dystrophin-associated protein complex (DAPC). Utrophin is a dystrophin homolog ...

Tags: dystrophin, utrophin, therapy.

Update on the Therapeutic approaches to muscular dystrophy

• Last Edited: 10 May 2011
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This is a summary of the article written by Aurelie Goyenvalle, Jane T Seto, Kay E Davies and Jeffrey Chamberlain, which was published by Oxford University Press on 5 April 2011.The article is a r...

Tags: exon skipping, gene therapy, Viral Vector, Dystrophin, rAAV, Antisense Oligonucleotide, PMO, PPMO, Duchenne, muscular dystrophy, Utrophin.