In November 2013, Action Duchenne, provided funding for one year of an innovative cutting-edge proposal entitled: “Exosomes: a novel therapeutic approach for the treatment of dystrophinopathies.” This project will be led by Dr Mattia Calissano, Newcastle University and expert collaborators Professor George Dickson, Royal Holloway and Francesco Muntoni.

Exosomes are natural lipid particles secreted by a vast variety of cells. By using these particles experimentally loaded with wild type dystrophin protein; the investigators aim to target and restore correct amounts of the dystrophin protein. This approach could offer a new and highly physiological way to restore dystrophin expression and thus functionality in the both the skeletal and cardiac muscles.