What are clinical trial endpoints? Endpoints in clinical trials are used to determine an appropriate goal of a clinical trial, for example increased survival or decreased disease severity. Biomarkers allow for the identification of disease, this could be a small molecule or gene produced as a result of a disease such as Duchenne. Biomarkers are used to determine clinical trial endpoints. There are three types of biomarkers: Diagnostic biomarkers (telling you something is wrong). Prognostic biomarkers (predicting disease course and/or severity). Therapeutic monitoring biomarkers (can predict whether a therapy will work or is working).