Muscle cellular stress refers to the way that muscle cells respond when they are exposed to stress, for example, stress caused by a lack of dystrophin. Cells can either respond by trying to protect themselves or by initiating their own death. The type of response that muscles produce can impact the potential benefit of treatments such as steroids that young people with Duchenne often receive. Researchers are conducting studies to identify how this stress may interfere with other treatments such as gene therapy and how it can be reduced.